Full-Time Senior Scientist – Discovery bioanalysis
Job Description
We are seeking a highly motivated Senior Scientist to join the integrated bioanalysis organisation. The position will take a lead role in the lab designing bioanalysis method strategies and interpreting data generated in support of new modality projects that will advance our drug pipeline. The position also requires working as the group representative in multidiscipline drug discovery teams.
Senior Scientist – Discovery bioanalysis
Cambridge UK, Gothenburg Sweden
Salary & Benefits Competitive
How we do it
It drives us to work together as one global team to achieve our goals. A supportive place where all are encouraged and achievement is recognised. Strengthening our knowledge through constructive feedback and coaching, as well as collaborating with the best.
AstraZeneca makes a vital contribution to the UK biopharmaceutical sector, employing 9% of the total workforce and supporting a further 39,000 UK jobs. Our 6,500 dedicated people, across five sites, share a common purpose: to push the boundaries of science to deliver life-changing medicines.
We’re investing to enhance our understanding of disease as we work towards creating the next generation of therapeutics and pioneering new approaches to better predict clinical success.
We are seeking a highly motivated Senior Scientist to join the integrated bioanalysis organisation. The position will take a lead role in the lab designing bioanalysis method strategies and interpreting data generated in support of new modality projects that will advance our drug pipeline. The position also requires working as the group representative in multidiscipline drug discovery teams.
The position is in our Discovery Bioanalysis Europe team which is part of the Clinical Pharmacology and safety sciences function and is responsible for the analysis of nucleotide, protein, monoclonal antibody and gene and cell therapeutics and non-clinical safety biomarkers in biological and invitro samples generated in support of non GLP pharmacokinetic, pharmacodynamic and investigational safety studies. We have a diverse array of scientists working across many technologies to ensure delivery of critical assays and data analysis that drive go/no go decisions and ensure the right combination of medicines get to the right patient, in the right dose, at the right time
What you’ll do
- This position will lead large, nucleotide and small molecule mass spectrometry pharmacokinetics and biomarker activities in the laboratory to better understand drug actions and their association with pharmacodynamics and safety.
- Your principle responsibility will be in the lab, designing, developing, and interpreting assays to support drug program transition through lead candidate selection and into clinical trials.
- You will be expected to represent the department on multidiscipline drug development teams, thus ability to support other technologies in the lab, especially ligand binding assays, will be a benefit.
- You will report into a head of Discovery Bioanalysis EU and be expected to take a lead role in pushing the boundaries of what is possible for mass spectrometry based bioanalyses in determining lead drug candidates and facilitating global clinical trials.
Essential Criteria
- A strong background in analytical biochemistry / chemistry with extensive experience of developing mass spectrometric methods for the quantitative measurement of biotherapeutics such as antibody drug conjugates, peptides, proteins, nucleotides and small molecules.
- Experience with chromatographic separation of various analytes by liquid chromatography
- Proficiency with mass spectrometry and proteomic software
- A high level of independence and with an ability to develop hypotheses and execute analysis plans for pharmacokinetics, pharmacodynamics and proteomics biomarker data.
- Attention to detail, good communication, and collaboration skills. Outstanding record keeping skills are critical for success.
- An ability to think and act creatively- independently, and within collaborations.
Desirable Criteria
- Experience with advanced data analysis tools for analyzing and visualizing pharmacokinetic and biomarker data.
- Operational experience with broader measurement technologies such as ligand binding and PCR for measurement of proteins and nucleotides.
- A proven track record of publication in large molecule bioanalysis field. Innovative and influential leader, capable of developing strategic approaches to analytical challenges
At AstraZeneca we’re dedicated to being a Great Place to Work. Where you are empowered to push the boundaries of science and unleash your entrepreneurial spirit. There’s no better place to make a difference to medicine, patients and society. An inclusive culture that champions diversity and collaboration. Always committed to lifelong learning, growth and development.
So, what’s next?
Complete your application before the below closing date.
This role is open from 10/06/2022 we welcome with your application no later than 24/06/2022
Where can I find out more?
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