Full-Time Senior Scientist (Oncology Safety Science, CPSS)
Job Description
We are seeking a highly motivated and skilled senior scientist with a strong background in cell biology to join the AstraZeneca Oncology Safety Sciences team in Cambridge. You will perform in vitro investigative studies to seek a mechanistic understanding of toxicities from projects developing novel biopharmaceutical oncology medicines and build new in vitro methods predictive of undesired in vivo effects. You will work closely with a team of scientists to apply ground-breaking technologies and push the boundaries of predictive safety science with our vision in mind: to deliver innovative safety science to help restore oncology patient’s lives and eliminate cancer as a cause of death.
Senior Scientist (Oncology Safety Science, CPSS)
Cambridge UK
Salary & Benefits Competitive
Make a more meaningful impact to patients’ lives around the globe
Here you’ll have the opportunity to make a meaningful difference to patients’ lives. With science at its heart, this is the place where breakthroughs born in the lab become transformative medicines – for the world’s most complex diseases. Answer unmet medical needs by pioneering the next wave of science, focusing on outcomes and shaping the patient ecosystem.
Join a key international site for AstraZeneca. Discover countless opportunities to grow and develop your personal career, experience and skills.
Always advancing our scientific knowledge and helping to shape the future of healthcare for the greatest and swiftest impact on disease.
We are seeking a highly motivated and skilled senior scientist with a strong background in cell biology to join the AstraZeneca Oncology Safety Sciences team in Cambridge. You will perform in vitro investigative studies to seek a mechanistic understanding of toxicities from projects developing novel biopharmaceutical oncology medicines and build new in vitro methods predictive of undesired in vivo effects. You will work closely with a team of scientists to apply ground-breaking technologies and push the boundaries of predictive safety science with our vision in mind: to deliver innovative safety science to help restore oncology patient’s lives and eliminate cancer as a cause of death.
What you will be doing
You will be collaborating with specialists across the Oncology organization to design and execute experimental strategies to assess and mitigate potential clinical toxicities of novel biopharmaceuticals such as antibody-drug conjugates (ADC’s) and nanomedicines. You will contribute to the early stages of project assessment (i.e., target selection, chemistry optimisation etc…) and address specific safety concerns to improve the therapeutic index of lead candidates and ensure that teams can make the right decisions regarding associated risks. You will apply and develop in vitro advanced cellular systems to help drive our predictive toxicology capabilities.
Additionally, you will:
- Address concerns about systemic toxicities, immunogenicity, non-specific clearance and develop strategies to overcome these to better exploit the properties of novel biopharmaceuticals and ADCs
- Work collaboratively with fellow researchers to plan, execute and analyse experimental strategies and data for discovery safety assessment e.g., proteomics array screens and biodistribution studies
- Explore innovative solutions and research proposals to pursue cutting edge novel biopharmaceutics and ADC science along with technologies such as organoids and micro-physiological systems for safety and efficacy assessment
- Assess and propose new drug candidate designs for enhanced efficacy and safety
- Regularly publish in high quality, peer-reviewed journals and present at scientific meetings
Essential Criteria
- A PhD in cellular biology, pharmacology, immunology, toxicology or similar field with at least 3 years of post-doctoral research.
- The ability to build an understanding of biology around novel targets and pathways, develop testable hypotheses, and drive scientific learning.
- Proven experience in cellular biology techniques applied to development of physiologically relevant cellular assays to dissect biological mechanisms (including -omics technologies, gene editing, confocal imaging, advanced cell systems such as micro-physiological systems and flow cytometry)
- A strong publication record demonstrating scientific excellence applying molecular techniques to advance understanding of cellular biology
- Outstanding oral presentation and written communication skills
- Highly motivated, innovative scientist with strong influencing skills, a collaborative team-oriented mindset and a strong desire to drive personal development.
Desirable Criteria
- Expertise in the design and execution of cellular experiments to determine the effects of biotherapeutics on biological systems
- Practical experience and scientific knowledge of in vitro models of haematopoiesis and/or peripheral neuropathy.
- Experience with antibody-based therapeutics, including antibody drug conjugates
- Understanding of the drug discovery process from experience in the biotech/pharmaceutical industry
At AstraZeneca we’re dedicated to being a Great Place to Work. Where you are empowered to push the boundaries of science and unleash your entrepreneurial spirit. There’s no better place to make a difference to medicine, patients and society. An inclusive culture that champions diversity and collaboration. Always committed to lifelong learning, growth and development.
So, what’s next?
Complete your application before the below closing date.
This role is open from 09/06/2022, we welcome your application no later than 23/06/2022
Where can I find out more?
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