Full-Time Scientist In Vivo Pharmacology – Immune Engagers group
Job Description
Do you feel passionate about the possibilities of science to change lives? Do you have a background within immuno-oncology?. If so, bring your expertise, apply your knowledge, follow the science and make a difference.
We currently have an exciting opportunity for a highly motivated senior scientist to join the T cell immune engagers team.
ASTRAZENECA
At AstraZeneca, we turn ideas into life changing medicines. Working here means being entrepreneurial, thinking big and working together to make the impossible a reality. We’re passionate about the potential of science to address the unmet needs of patients around the world. We commit to those areas where we believe we can really change the course of medicine and bring big new ideas to life.
Business Area
AstraZeneca’s vision in Oncology is to push the boundaries of science to change the practice of medicine, transform the lives of patients living with cancer, and to ultimately eliminate cancer as a cause of death. A broad pipeline of next-generation medicines is focused principally on four disease areas – breast, ovarian, lung and haematological cancers.
What you’ll do
We are seeking a highly motivated Senior Scientist in the T cell immune engagers team with deep scientific and technical expertise in the evaluation of immunotherapies using preclinical in vivo models to join our team in Cambridge, UK.
As a Senior Scientist you will be a key member of a team focussed on supporting immune-oncology projects through the drug discovery process. You will bring your theoretical and practical expertise in the application of preclinical models to deliver decision making data for our immune-oncology research projects.
Main Duties and Responsibilities
You will spend the majority of time in the laboratories within the Oncology Research group, and you will support projects aligned with one of AZ Oncology’s key focus areas, immune engagers. You will focus on develop, design, run and analyse in vivo, ex vivo, and some in vitro experiments to understand the effect of drugs in complex model systems. You bring expertise in in-vivo techniques and will perform studies using in vivo tumour models. You may also perform in vitro immune assays with primary cells (human or murine) to support projects in the immuno-oncology pipeline and in vitro assays using cultured cell lines (e.g. luciferase reporter cell assays).
Essential Requirements
PhD (or equivalent) in a biological science with significant hands-on in vivo experience OR BSc /MSc (or equivalent) plus equivalent experience in scientific discipline such as immunology or cancer research.
Hands-on experience with animal handling and procedures including dissection and tissue collection, running in vivo models, particularly oncology models.
Understanding and enthusiasm for tumour immunology and cancer therapies.
Possession of a range of ex vivo/ in vitro skills that can be applied to cancer immunology research. This includes issue culture techniques for cell-based immunoassays, experience working with human immune cells, ex vivo immunobiology techniques such as: complex flow cytometry (including intracellular cytokine or multicolour cell surface staining); MSD; and ELISA.
Data processing, statistical analysis and interpretation.
Experience preparing written scientific reports (e.g. manuscripts) and oral presentations (e.g. slides, posters).
Willingness to work flexibly; including weekends as necessary.
Desirable Requirements
Experience working with humanised mouse models
Experience working in the field of immuno-oncology within the pharmaceutical or biotechnology industry, or in academia.
Experience using preclinical mouse models in the field of tumour immunology
Home Office Licence (Modules 1-4) or equivalent qualification for animal work and experience working under Home Office Regulations (as a Personal Licence Holder)
Publications in top-tier scientific journals
Locations: Cambridge UK
Salary: Competitive + Excellent Benefits
So, what’s next?
If you’re curious to know more then please reach out to Sophie Halpin. We welcome your application, no later 18th March 2022
As part of the application process for some roles at AstraZeneca, candidates may be asked to complete a series of online games, created by pymetrics, to assess certain candidate qualities to help evaluate potential match for the position. If the pymetrics process applies to this role, you will receive an email invitation with additional information following application. Once completed AZ will automatically receive your results – pymetrics will not be used solely in our decision-making process but will help us gather additional insight.
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